* Case report(s), package insert, or uncertain frequency.
** Infrequent side effect.
*** Frequent side effect.
**** Very frequent side effect.
Note: Medications
and their accompanying side effects that are cited frequently as causing sexual
disorders are in bold type.
Adapted from: Finger WW, Lund M, Slagle MA:
Medications that may contribute to sexual disorders: a guide to assessment and
treatment in family practice, JFam Pract
44:33-43, 1997.
benazepril (Lotensin)
chlorthalidone (Hygroton, Thalidone)***
clonidine (Catapres)**
guanadrel (Hylorel)***
guanethidine (Ismelin)****
indapamide (Lozol)
labetalol (Normodyne, Trandate)*
lisinopril (Prinivil, Zestril)**
mecamylamine (Inversine)*
methyldopa (Aldomet) (men and women)***
metoprolol (Lopressor, Toprol XL)*
propanolol (Inderal) (men and women)**
reserpine (men and women)***
spironolactone (Aldactone) (men and women)***
timolol (Blocadren) (men and women)*
bupropion (Wellbutrin)**
clomipramine (Anafranil) (men and women)****
desipramine (Norpramin, Pertofrane)*
doxepin (Adapin, Sinequan)
fluoxetine (Prozac)***
imipramine (Tofranil, Janimine)*
maprotiline (Ludiomil)*
nortriptyline (Aventyl, Pamelor)*
phenelzine (Nardil)*
protripyline (Vivactil)
tranylcypromine (Parnate)*
barbiturates buspirone (BuSpar)**
chlorpromazine (Thorazine)*
clonazepam (Klonopin)
diazepam (Valium, Zetran)
fluphenazine (Prolixin, Permitil)****
lithium (Eskalith, Lithonate)*
lorazepam (Ativan)*
oxazepam (Serax)*
pimozide (Orap)*
amiodarone (Cordarone)*
carbamazepine (Tegretol, Atretol, etc)
cimetidine (Tagamet) (men and women)*
clofibrate (Atromid-S)
cyclobenzaprine (Flexeril)
danazol (Danocrine)***
dichlorphenamide (Daranide)*
digoxin (Lanoxin)***
ethinyl estradiol (Estinyl)***
fenphluramine (Fastin) (frequent in women with large doses or long-term use)*
gemfibrozil (Lopid)
glycopyrrolate (Robinul)*
hydroxyzine (Atarax, Anxanil, Vistaril)
interferon
ketoconazol (Nizoral)***
medroxyprogesterone (Depo-Provera, Amen, Cycrin, etc)*
methadone (Dolophine)****
methazolamide (Neptazane) (men and women)*
metoclopramide (Reglan)*
metronidazole (Flagyl, Protostat)*
mexiletine (Mexitil)
morphine (MS Contin, Roxanol)
niacin (Nicolar, Niacor, Nicobid)***
norethindrone (Norlutin)
phendimetrazine (Adphen, Bacarate, Anorex, Statobex)*
phenobarbital
phenytoin (Dilantin)
primidone (Mysoline)
ranitidine (Zantac)
marijuana
MDMA**
methaqualone (in women)*
morphine (MS Contin, Roxanol)
diphenhydramine (Benadryl, Genahist, Nordryl, etc)
niacin (Nicolar, Niacor, Nicobid)***
ranitidine (Zantac 75)
prochlorperazine (Compazine)
alcohol (both acute and chronic effects)***
amphetamines (may increase desire at low dose)
cyclobenzaprine (Flexeril)
danazol (Danocrine)***
ethosuximide (Zarontin)*
physostigmine (Antilirium)*
levodopa (Larodopa, Dopar)****
trazodone (Desyrel)
atenolol (Tenormin)***
benazepril (Lotensin)*
chlorthalidone (Hygroton, Thalitone)***
clonidine (Catapres)****
diltiazem (Cardizem, Dilacor XR)*
enalapril (Vasotec)**
guanabenz (Wytensin)***
guanadrel (Hylorel)***
guanethidine (Ismelin)****
hydralazine (Apresoline)*
hydrochlorthiazide (Esidrix, HydroDIURIL), Oretic)****
indapamide (Lozol)**
labetalol (Normodyne, Trandate)****
lisinopril (Prinivil, Zestril)**
mecamylamine (Inversine)*
methyldopa (Aldomet)***
metoprolol (Lopressor, Toprol XL)*
metyrosine (Demser)**
minoxidil (Loniten)*
nifedipine (Procardia, Adalat)**
phentolamine (Regitine)*
pindolol (Visken)*
prazosin (Minipress)**
propanolol (Inderal)****
reserpine***
spironolactone (Aldactone)***
timolol (Blocadren)*
trimethaphan (Arfonad)
verapamil (Calan, Isoptin, Verelan)*
bupropion (Wellbutrin)**
desipramine (Norpramin, Pertofrane)*
impramine (Tofranil, Janimine)***
maprotiline (Ludiomil)*
nortriptyline (Aventyl, Pamelor)*
paroxitine (Paxil)
phenelzine (Nardil)*
protriptyline (Vivactil)
tranylcypramine (Parnate)**
venlafaxine (Effexor)**
buspirone (BuSpar)*
chlordiazepoxide (Librium, Mitran, Reposans-10)
chlorpromazine (Thorazine)***
chlomipramine (Anafranil)****
clonazepam (Klonopin)
droperidol (Inapsine)*
fluphenazine (Prolixin, Permitil)****
Haloperidol (Haldol)*
lithium (Eskalith, Lithonate)***
meprobamate (Equanil, Miltown)*
mesoridazine (Serentil)*
pimozide (Orap)***
prochlorperazine (Compazine)
sulpiride (Supril, Sulpitil)***
thioridazine (Mellaril)****
thiothixine (Navane)
amiodarone (Cordarone)*
atropine*
baclofen (Lioresal)
benztropine (Cogentin)*
biperiden (Akineton)*
bromocriptine (Parlodel)*
carbamazepine (Tegretol, Atretol, etc)***
cimetidine (Tagamet)***
clinidium (Quarzan)*
clofibrate (Atromid-S)***
cyclobenzaprine (Flexeril)
dichlorphenamide (Daranide)***
dicyclomine (Bentyl, Di-Spaz, etc)*
digoxin (Lanoxin)***
diopyramide (Norpace)**
disulfiram (Antabuse)
ethionamide (Trecator-SC)*
etretinate (Tegison)*
famotidine (Pepsid)**
fenfluramine (Fastin)**
furazolidone (Furoxone)*
gemfibrozil (Lopid)*
homatropine
methylbromide (Homapin, Equipin, Lantro)*
hydrochlorthiazide (Esidrix, HydroDIURIL, Oretic, etc)****
hydroxyzine (Atarax, Anxanil, Vistaril)*
indomethacin (Indocin)*
interferon*
mazindol (Mazanor, Sanorex)*
meclizine (Antivert, Bonine)*
medroxyprogesterone (Depo-Provera, Amen, Cycrin, etc)*
methadone (Dolophine)****
methazolamide (Neptazane)***
methotrexate (Folex, Rheumatrex)*
methysergide (Sansert)*
metoclopramide (Reglan)*
mexiletine (Mexitil)*
morphine (MS Contin, Roxanol)
naproxen (Anaprox, Naprelan, Naprosyn)
nizatidine (Axid)
norethindrone (Norlutin)***
omeprazole (Prilosec)*
orphenadrine (Flexon, Flexoject, Norflex, Myolin)*
oxybutynin (Ditropan)*
phendimetrazine (Adphen, Bacarate, Anorex, Statobex)
phenobarbitol***
phentermine (Fastin, Lonamin)
phentolamine (Regitine)*
phenytoin (Dilantin)***
primidone (Mysoline)***
probucol (Lorelco)
procarbazine (Matulane)*
prochlorperazine (Compazine)
procyclidine (Kemadrin)*
propantheline bromide (Pro-Banthine)*
ranitidine (Zantac)*
scopolamine (Transderm-Scop)*
sulfasalazine (Azulfidine)*
thiabendazole (Mintezol)***
trihexyphenidyl (Artane)*
amyl nitrite
barbiturates
cocaine***
MDMA****
methaqualone
morphine
tobacco**
antihistamines*
cimetidine (Tagamet HB)***
dimenhydrinate (Dramamine, Marmine, Calm-X, etc)*
diphenhydramine (Benadryl, Genahist, Nordryl, etc)*
famotidine (Pepcid AC)**
naproxen (Aleve)
ranitidine (Zantac 75)*
Orgasm/Ejaculation Disorder In Men: Delayed or Absent*
Information on orgasm/ejaculation is often not presented as gender-specific (versus information on orgasm in women).
clonidine (Catapres)**
guanadrel (Hylorel)***
guanethidine (Ismelin)****
labetalol (Normodyne, Trandate)****
methyldopa (Aldomet)***
metyrosine (Demser)**
phenoxybenzamine (Dibenzyline)***
prazosin (Minipress)
reserpine***
trimethaphan (Arfonad)*
desipramine (Norpramin, Pertofrane)*
doxepin (Adapin, Sinequan)*
fluoxetine (Prozac)****
imipramine (Tofranil, Janimine)
phenelzine (Nardil)***
sertraline (Zoloft)****
trazodone (Desyrel)*
trimipramine (Surmontil)*
venlafaxine (Effexor)***
barbiturates***
buspirone (BuSpar)*
chlordiazepoxide (Librium, Mitran, Reposans-10)*
chlorpromazine (Thorazine)*
clomipramine (Anafranil)****
clonazepam (Klonapin)*
diazepam (Valium, Zetran)
fluphenazine (Prolixin, Permitil)*
haloperidol (Haldol)*
mesoridazine (Serentil)*
perphenazine (Trilafon)****
pimozide (Orap)*
prochlorperazine (Compazine)
thioridazine (Mellaril)****
baclofen (Lioresal)**
isotretinoin (Accutane)*
methadone (Dolophine)****
methotrexate (Folex, Rheumatrex)*
naproxen (Anaprox, Naprelan, Naprosyn)*
phendimetrazine (Adphen, Bacarate, Anorex, Statobex)
phentermine (Fastin, Ionamin)
prochlorperazine (Compazine)
trimeprazine (Temaril)*
amphetamines: low dose*; high doses and chronic use***
amyl nitrite*
barbiturates***
cocaine
diazepam (Valium) MDMA****
methaqualone*
naproxen (Aleve)*
Interference With Orgasm in Women*
Information on orgasm/ejaculation is often not presented as gender-specific (versus information on orgasm in women).
amphetamines*
clonidine (Catapres)**
diazepam (Valium, Zetran)* (cited frequently when abused)
imipramine (Tofranil, Janimine)***
methadone (Dolophine)****
methyldopa (Aldomet)***
phendimetrazine (Adphen, Bacarate, Anorex, Statobex)*
buspirone (BuSpar)*
chlorpromazine (Thorazine)**
clozapine (Clozaril)*
cocaine*
fluphenazine (Prolixin, Permitil)*
heparin*
hydralazine (Apresoline)*
labetalol (Normodyne, Trandate)*
mesoridazine (Serentil)*
molindone (Moban)*
omeprazole (Prilosec)*
perphenazine (Trilafon)*
prazosin (Minipress)*
prochlorperazine (Compazine)*
risperidone (Risperdal)*
tamoxifen (Nolvadex)*
testosterone*
thioridazine (Mellaril)*
thiothixene (Navane)*
trazodone (Desryl)***
trifluoperazine (Stelazine)*
* Case report(s), package insert, or uncertain frequency.
** Infrequent side effect.
*** Frequent side effect.
**** Very frequent side effect.
Note: Medications
and their accompanying side effects that are cited frequently as causing sexual
disorders are in bold type.
Adapted from: Finger WW, Lund M, Slagle MA:
Medications that may contribute to sexual disorders: a guide to assessment and
treatment in family practice, JFam Pract
44:33-43, 1997.