(Merrill J.P, Murray J.E, Harrison J.H, Guild W.R. Successful homotrasplantation of the human kidney
(The indications and limitations of
Prostatic Surgery in the presence of cardiac disease. Harrison Hartwell J. The American Journal of the
Medical Sciences:204(4):469‐482, Oct 1.942); (Murray J.E, Merrill J.P, Harrison J.H, Wilson R.E, Dammin
G.J. Prolonged survival of human kidney homografts by immunosuppressive drug therapy. N Engl J Med
`
J. Harrison Hartwell
El `Equipo de la Gloria' del Peter Bent Brigham Hospital 1.965
Earl W. Sutherland (1.915‐1.974) publicaria dos trabajos de investigación
descubriendo la significación fisiologica de los nucleotidos ciclicos en la regulación de
la celula y de la funcion tisular.Aisló los compuestos denominados cAMP (Adenina monofosfato ciclico).
Esto lo hizo merecedor del Premio Nobel de Medicina y Fisiologia el año 1.971.
Seria fundamental para el entendimiento del primer tratamiento oral efectivo para la
disfuncion erectil a finales del siglo XX (Formation of a Cyclic Adenine Ribonucleotide by Tissue Particles
(Rall T.W, Sutherland E.W (1.958) J. Biol. Chem. 232, 10651076); (Fractionation and Characterization of a
Cyclic Adenine Ribonucleotide Formed by Tissue Particles. Sutherland E.W, Rall T.W (1.958) J. Biol. Chem.
232, 10771092).
FORMATION OF A CYCLIC ADENINE RIBONUCLEOTIDE
BY TISSUE PARTICLES
BY T. W. RALL AND EARL W. SUTHERLAND
(From the Department of Pharmacology, School of Medicine,
Western Reserve University, Cleveland, Ohio)
FRACTIONATION AND CHARACTERIZATION OF A CYCLIC
ADENINE RIBONUCLEOTIDE FORMED
BY TISSUE PARTICLES
BY EARL W. SUTHERLAND AND T. W. RALL
(From the Department of Pharmacology, School of Medicine,
Western Reserve University, Cleveland, Ohio)
Earl W. Sutherland (1.915‐1.974)
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